A 10-year retrospective record review examined patients whose Charcot-Marie-Tooth (CMT) symptoms began after age 50. Researchers found that 8.9% of older adults tested for suspected hereditary nerve conditions had genetically confirmed CMT, often marked by high foot arches, a family history of neuropathy, or specific nerve signal test results.
A study using standing CT scans evaluated how ankle-foot orthoses (AFOs) affect foot posture in 20 adults with Charcot-Marie-Tooth disease. Researchers found that standing in AFOs did not reduce cavovarus (high-arched and inward-curved) foot deformity compared to standing barefoot, suggesting that brace benefits may come from ankle stability rather than correcting foot shape.